Abstract: Being able to control polymorphism of a crystal is of great importance to many industries,\nincluding the pharmaceutical industry, since the crystalâ??s structure determines significant physical\nproperties of a material. While there are many conventional methods used to control the final\ncrystal structure that comes out of a crystallization unit, these methods fail to go beyond a few\nknown structures that are kinetically accessible. Recent studies have shown that externally applied\nfields have the potential to effectively control polymorphism and to extend the set of observable\npolymorphs that are not accessible through conventional methods. This computational study focuses\non the application of high-intensity dc electric fields (e-fields) to induce solid-state transformation of\nglycine crystals to obtain new polymorphs that have not been observed via experiments. Through\nmolecular dynamics simulations of solid-state........
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